Antiarrhythmic properties of novel antianginal drugs in dog and human cardiac preparations
نویسندگان
چکیده
Class I/B antiarrhythmic property of ranolazine, a novel antianginal agent, in dog and human cardiac preparations Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets A multi-scale investigation of repolarization variability and its role in cardiac arrhythmogenesis Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue
منابع مشابه
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.
BACKGROUND Ranolazine is a novel antianginal agent capable of producing antiischemic effects at plasma concentrations of 2 to 6 micromol/L without reducing heart rate or blood pressure. The present study examines its electrophysiological effects in isolated canine ventricular myocytes, tissues, and arterially perfused left ventricular wedge preparations. METHODS AND RESULTS Transmembrane acti...
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